Winstuitkering in ziekenhuizen: daar krijgen we spijt van!

download (34)De Tweede Kamer heeft het wetsvoorstel voor winstuitkering in ziekenhuizen en andere aanbieders van medisch-specialistische zorg op 1 juli zonder al te veel discussie aangenomen. Ten onrechte, aldus hoogleraar Evelien Tonkens, het wetsvoorstel heeft verstrekkende gevolgen. Voor alle duidelijkheid: winst maken, is geen probleem als dat betekent dat er geld wordt opgepot voor slechtere tijden. Het probleem van de Wet op winstuitkering echter is dat de winst wordt uitgekeerd aan partijen die er niet zelf voor gewerkt hebben.[…]

via Winstuitkering in ziekenhuizen: daar krijgen we spijt van!.

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Depression Deconstructed – NIH Study

images (22)October 17, 2014 • Press Release

A drug being studied as a fast-acting mood-lifter restored pleasure-seeking behavior independent of – and ahead of – its other antidepressant effects, in a National Institutes of Health trial. Within 40 minutes after a single infusion of ketamine, treatment-resistant depressed bipolar disorder patients experienced a reversal of a key symptom – loss of interest in pleasurable activities – which lasted up to 14 days. Brain scans traced the agent’s action to boosted activity in areas at the front and deep in the right hemisphere of the brain.

“Our findings help to deconstruct what has traditionally been lumped together as depression,” explained Carlos Zarate, M.D., of the NIH’s National Institute of Mental Health. “We break out a component that responds uniquely to a treatment that works through different brain systems than conventional antidepressants – and link that response to different circuitry than other depression symptoms.”

This approach is consistent with the NIMH’s Research Domain Criteria project, which calls for the study of functions – such as the ability to seek out and experience rewards – and their related brain systems that may identify subgroups of patients in one or multiple disorder categories.

Zarate and colleagues reported on their findings Oct. 14, 2014 in the journal Translational Psychiatry.

Although it’s considered one of two cardinal symptoms of both depression and bipolar disorder, effective treatments have been lacking for loss of the ability to look forward to pleasurable activities, or anhedonia. Long used as an anesthetic and sometimes club drug , ketamine and its mechanism-of-action have lately been the focus of research into a potential new class of rapid-acting antidepressants that can lift mood within hours instead of weeks.

Based on their previous studies, NIMH researchers expected ketamine’s therapeutic action against anhedonia would be traceable – like that for other depression symptoms – to effects on a mid-brain area linked to reward-seeking and that it would follow a similar pattern and time course.

To find out, the researchers infused the drug or a placebo into 36 patients in the depressive phase of bipolar disorder. They then detected any resultant mood changes using rating scales for anhedonia and depression. By isolating scores on anhedonia items from scores on other depression symptom items, the researchers discovered that ketamine was triggering a strong anti-anhedonia effect sooner – and independent of – the other effects.

Levels of anhedonia plummeted within 40 minutes in patients who received ketamine, compared with those who received placebo – and the effect was still detectable in some patients two weeks later. Other depressive symptoms improved within 2 hours. The anti-anhedonic effect remained significant even in the absence of other antidepressant effects, suggesting a unique role for the drug.

Next, the researchers scanned a subset of the ketamine-infused patients, using positron emission tomography (PET), which shows what parts of the brain are active by tracing the destinations of radioactively-tagged glucose – the brain’s fuel. The scans showed that ketamine jump-started activity not in the middle brain area they had expected, but rather in the dorsal (upper) anterior cingulate cortex, near the front middle of the brain and putamen, deep in the right hemisphere.

Boosted activity in these areas may reflect increased motivation towards or ability to anticipate pleasurable experiences, according to the researchers. Depressed patients typically experience problems imagining positive, rewarding experiences – which would be consistent with impaired functioning of this dorsal anterior cingulate cortex circuitry, they said. However, confirmation of these imaging findings must await results of a similar NIMH ketamine trial nearing completion in patients with unipolar major depression.

Other evidence suggests that ketamine’s action in this circuitry is mediated by its effects on the brain’s major excitatory neurotransmitter, glutamate, and downstream effects on a key reward-related chemical messenger, dopamine. The findings add to mounting evidence in support of the antidepressant efficacy of targeting this neurochemical pathway. Ongoing research is exploring, for example, potentially more practical delivery methods for ketamine and related experimental antidepressants, such as a nasal spray .

However, Ketamine is not approved by the U.S. Food and Drug Administration as a treatment for depression. It is mostly used in veterinary practice, and abuse can lead to hallucinations, delirium and amnesia.

Dorsal anterior cingulate cortex

PET scans revealed that ketamine rapidly restored bipolar depressed patients’ ability to anticipate pleasurable experiences by boosting activity in the dorsal anterior cingulate cortex (yellow) and related circuitry. Picture shows PET scan data superimposed on anatomical MRI.

Source: Carlos Zarate, M.D., NIMH Experimental Therapeutics and Pathophysiology Branch



Anti-anhedonic effect of ketamine and its neural correlates in treatment-resistant bipolar depression.  Lally N, Nugent AC, Luckenbaugh DA, Ameli R, Roiser JP, Zarate CA. Transl Psychiatry.2014 Oct 14;4:e469. doi: 10.1038/tp.2014.105. PMID: 25313512

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Blog: Vechten voor je kind |

Blog: Vechten voor je kind |

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Peshmerga advance team in Kobane

Peshmerga advance team in Kobane 

An advance team of 10-15 Peshmerga officers entered Kobane through the Turkish border on Wednesday afternoon to plan a collective strategy with the People’s Protection Units (YPG), the Syrian-Kurdish force that has been defending the city against an Islamic State (ISIS) takeover.

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Het medisch beroepsgeheim offer je niet om boeven te vangen

Het medisch beroepsgeheim offer je niet om boeven te vangen.

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Het sociale contract tussen arm en rijk is al lang verbroken

groene-a7d3ee89b5cc9b079809d17e8ac82b84 (1)Volgende week is het Piketty-week. Ter gelegenheid van de lancering van de Nederlandse vertaling van zijn Kapitaal in de 21ste eeuw doet de Franse econoom ons land aan.

Ewald500 door Ewald Engelen


Woensdag 5 november zit hij eerst in de Tweede Kamer voor een gesprek met de leden van de Vaste Kamercommissie Financiën. ’s Avonds houdt hij een lezing in Paradiso om na afloop in gesprek te gaan met Joris Luyendijk.

Lees: De Groene.

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